Study of Erythrocyte Lipid Peroxidation and Deformability inIndividuals with Sickle Cell Trait.
Annual rept. (Final) 15 Jan 1987-30 Jun 1989
MEHARRY MEDICAL COLL NASHVILLE TN
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Tread Mill exercise did not have any significant effect on the lipid peroxidation potential and deformability of RBC in normal AA subjects. However, it caused an increase in the lipid peroxidation potential and a loss of deformability of RBC in sickle cell trait AS subjects. Increased TBC lipid peroxidation in AS during exercise was accompanied with an accumulation of excessive amounts of superoxide radicals due to increase in superoxide dismutase activity and less decomposition of these free radicals. Furthermore, the modulation of peroxide scavengers of RBC in AS during exercise was associated with an increase in the intracellular calcium concentration and an increase in the RBC membrane density. Thus the loss of deformability in AS during exercise may be related to the change in RBC membrane density. Keywords Sickle cell trait Physical stress Lipid Peroxidation Deformability RA III.
- Genetic Engineering and Molecular Biology
- Anatomy and Physiology