Accession Number:

ADA222018

Title:

The Acute, Delayed Neurotoxicity Evaluation of Two Jet Engine Oil Formulations

Descriptive Note:

Final rept. May-Oct 1989

Corporate Author:

NSI TECHNOLOGY SERVICES CORP DAYTON OH

Report Date:

1990-04-01

Pagination or Media Count:

25.0

Abstract:

This study was designed to determine the potential of two jet oils to produce acute, delayed neurotoxicity. The hydrocarbon-based ester oil formulation contained 3 tricresyl phosphate isomers, including triorthocresyl phosphate TOCP in one of the formulations. Hens were orally dosed over a five- day period and then observed for a total period of 30 days. All TOCP-positive control hens demonstrated signs of acute, delayed neurotoxicity. Hens from both jet engine oil groups remained asymptomatic throughout the observation period. No neurotoxic hazard would be expected for military or civilian personnel involved in the manufacture, transportation, or handling of these compounds. Keywords Engine oils Lubricating oils Neurotoxicity.

Subject Categories:

  • Toxicology
  • Lubricants and Hydraulic Fluids

Distribution Statement:

APPROVED FOR PUBLIC RELEASE