Accession Number:

ADA220960

Title:

Alterations in Brain Monoamine Neurotransmitter Release at High Pressure

Descriptive Note:

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Report Date:

1989-01-01

Pagination or Media Count:

7.0

Abstract:

High pressure exposure produces neurological changes which manifest as tremors, EEG changes and convulsions. Since previous studies have implicated the involvement of the monoaminergic system in these symptoms, it was of interest to study monoamine release at high pressure. Synaptosomes isolated from guinea pig brain were used to follow monoamine efflux at 68 ATA. The major observation was a decrease in the initial calcium dependent release of all three monoamines in response to K induced depolarization. This response is similar to that previously observed for GABA, glycine and glutamate. This generalized pressure induced depression of initial transmitter release suggests a mechanism common to the release process for both excitatory and inhibitory neurotransmission. Keywords Neurotransmitter High pressure nervous syndrome Synaptosomes Monoamines Hyperbaric pressure Reprints.

Subject Categories:

  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE