Accession Number:

ADA220814

Title:

Therapeutic Approaches to the Treatment of Botulism

Descriptive Note:

Annual rept. 1 Sep 1988-5 Jul 1989

Corporate Author:

JEFFERSON MEDICAL COLL PHILADELPHIA PA

Personal Author(s):

Report Date:

1989-10-01

Pagination or Media Count:

26.0

Abstract:

Pharmacological methods are being sought to prevent or reverse the effects of botulinum neurotoxin. During the past year, emphasis has been placed on drugs that interact with potassium channels. Work during the past year has focused on three problems i aminopyridines and their analogues, ii dendrotoxin, and iii rubidium flux. The work on aminopyridines cofirms that they are very narrow in their utility as anti-botulism agents. The studies on dendrotoxin resulted in the provocative finding that the agent did not antagonize any clostridial neurotoxin, nor could it reverse the effects of low calcium or high magnesium. The final aspect of the research was to establish a protocol for studying rubidium flux. This may represent a rational approach for finding clostridial toxin antagonists. Keywords Botulinum neurotoxin Neuromuscular blockade Experimental therapeutics RA1.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE