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Trehalose Dimycolate Enhances Survival of Fission Neutron-Irradiated Mice and Klebsiella pneumoniae-Challenged Irradiated Mice
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
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The effects of radiation on mammalian hematopoietic, myelopoietic, and gastrointestinal systems are diverse and depend on both the exposure dose and the quality of radiation. The survival of B6D2FI female mice exposed to lethal doses of fission neutron radiation is increased when trehalose dimycolate TDM preparations are given either 1 h after exposure or 1 day before exposure to radiation. TDM in an emulsion of squalene, Tween 80, and saline was the most effective formulation for increasing the 30-day survival of mice when given 1 day before 90 or 1 h after 88 exposure to radiation. An aqueous suspension of a synthetic analog of TDM was less effective at increasing 30-day survival 60 when given 1 day prior to radiation exposure and not effective when given 1 h after radiation. Mice receiving a sublethal dose 3.5 Gy of fission neutron radiation and either the TDM emulsion or synthetic TDM 1 h after irradiation were substantially more resistant to challenge with 10, 100, 1000, or 5,000 times the LD 5030 dose of Klebsiella pneumoniae than untreated mice. Reprints.
APPROVED FOR PUBLIC RELEASE