Accession Number:

ADA220725

Title:

Therapeutic Approaches to the Treatment of Botulism

Descriptive Note:

Final rept. 1 Sep 1985-5 Jul 1989

Corporate Author:

JEFFERSON MEDICAL COLL PHILADELPHIA PA

Personal Author(s):

Report Date:

1989-10-01

Pagination or Media Count:

40.0

Abstract:

Research has been conducted in four areas that pertain to the development of antagonists of botulinum neurotoxin, as follows 1 Studies on monoclonal antibodies indicate that they are useful research tools, but they appear to have little therapeutic potential. 2 Research on aminopyridines and their analogues shows that they possess anti-botulinum activity, but only of a narrow utility. 3 Experiments with dendrotoxin have resulted in the provocative finding that this agent does not antagonize any clostridial toxin, nor does it reverse the effects of low calcium or high magnesium. 4 Initial studies on rubidium flux indicate that this may represent a rational approach for finding clostridial toxin antagonists. Keywords Botulinum neurotoxin Neuromuscular blockade Experimental therapeutics.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE