Accession Number:

ADA220662

Title:

Studies of Epstein-Barr Virus Infection and Immunoregulation in Patients with Aids and Aids-Related Disorders

Descriptive Note:

Midterm rept. 21 Jul 1987-20 Mar 1989,

Corporate Author:

FOOD AND DRUG ADMINISTRATION BETHESDA MD OFFICE OF BIOLOGICS RESEARCH AND REVIEW

Personal Author(s):

Report Date:

1989-05-21

Pagination or Media Count:

27.0

Abstract:

Monocytes and monocyte products have been shown to enhance markedly the growth of EBV-infected B cells patients with AIDS have an increased frequency of EBV-infected B cells in their peripheral blood. The investigators have further shown that activated peripheral blood monocytes secretes beta 2IL- 6 which promotes the growth of EBV-infected cells but, in general, IL-6 is not produced by EBV infected B cells. aw

Subject Categories:

  • Medicine and Medical Research
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE