Accession Number:

ADA218479

Title:

The Relationship between Esmolol and the Onset and Duration of Action of Succinylcholine in Patients Undergoing General or Orthopedic Surgery

Descriptive Note:

Master's thesis,

Corporate Author:

AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH

Personal Author(s):

Report Date:

1983-05-01

Pagination or Media Count:

80.0

Abstract:

The purpose of this study was to investigate a potential interaction between esmolol and succinylcholine. Specifically, the researcher investigated whether or not esmolol prolongs the onset and duration of action of succinylcholine Sch. The investigator studied 25 adult, ASA I and II, male and female patients. Patients underwent orthopedic or general surgical procedures under general anesthesia requiring endotracheal intubation. All subjects received identical preoperative medication glycopyrrolate 0.2 mg intravenous IV. Statistical analysis revealed a significant slowing in onset of Sch induced muscle relaxation p.045. Conversely, there was no statistically significantly delay in 50 p.179 and 90 recovery p.109. However, statistical analysis indicated that esmolol did prolong the recovery from Sch induced neuromuscular blockade. Further investigation of this potential interaction is warranted. KT

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE