The Effects of Graded Exercise at Sea Level on Plasma Proenkephalin Peptide F and Catecholamine Responses
ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
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The purpose of this study was to evaluate the effects of graded treadmill exercise on plasma proenkephalin Peptide F immunoreactivity ir and catecholamine responses. Little data exists regarding the sea level responses of plasma Peptide F ir to exercise. Thirty-five healthy male subjects performed a graded exercise test on a motor-driven treadmill at the exercise intensities of 25, 50, 75, and 100 of VO2max. Significant increases above rest were observed for plasma Peptide F ir and norepinephrine at 75 and 100 of VO2max and at 5 min into recovery. Significant increases in plasma epinephrine were observed at 75 and 100 of VO2max. Whole blood lactate significantly increased above resting values at 50, 75 and 100 of the VO2max and at 5 min into recovery. These data demonstrate that exercise increases plasma Peptide F ir levels at sea level. While the exercise response patterns of Peptide F ir are similar to catecholamines and blood lactate responses, no bi-variate relationships were observed. These data show that sea level response patterns to graded exercise are similar to those previously observed at moderate altitude 2200 m. Keywords Endogenous opioid peptides Lactate Epinephrine Norepinephrine Aerobic exercise.
- Stress Physiology