Hypobaric Hypoxia (380 Torr) Decreases Intracellular and Total Body Water in Goats
ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
Pagination or Media Count:
The effect of 16 days of hypobaric hypoxia on body fluid distribution was studied in four unanesthetized adult goats Capra lircus. Total body water TBW, extracellular fluid volume ECF, and plasma volume PV were determined with 3H2O, 14C-inulin, and indocyanine green, respectively. Blood volume BV PV x 100100 - HEMATOCRIT, red cell volume RCV BV - PV, intracellular fluid ICF TBW - ECF and interstitial fluid ISF ECF - PV volumes were calculated. Body mass -7.1, TBW -9.1, and ICF volume -14.4 decreased, while ECF 11.7, and ISF 27.7 volumes increased with exposure p 0.05. The decrease in TBW accounts for 89 of the loss of body mass. Hematocrit increased from 24.0 or - 1.0 SEM to 34.2 or - 2.2 p 0.05. BV was unchanged an increase in RCV 39.5 counterbalanced the decrease in PV -15. 3 p 0.05. Goats were similar to humans in that prolonged hypobaric hypoxia resulted in decreases in TBW volume, ICF volume, and PV. Keywords High altitude Total body water Extracellular fluid Plasma volume RER.
- Stress Physiology