The Electrical Potential of Proteins
Final rept. 1 Sep 1986-31 Dec 1989
COLUMBIA UNIV NEW YORK DEPT OF BIOCHEMISTRY AND MOLECULAR BIOPHYSICS
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Our efforts during the course of this research grant have been devoted to characterizing the role of electrostatic interactions in molecular recognition processes. To this end we have continued to develop and improve our electrostatics methodology which is based on numerical solutions to the Poisson- Boltzmann equation. In addition we have applied this methodology to a number of biochemical processes involved in molecular recognition. These include electrostatically enhanced diffusion, the effect of surface charges on electrical potentials in binding sites, the nature of the electrical potential around nucleic acids, and electrostatic contributions to the folding energies of helical proteins. The latter work has been made possible by a new method we have developed to extract electrostatic contributions to solvation energies from the potentials obtained from the Poisson-Boltzmann equation.
- Anatomy and Physiology