Accession Number:

ADA215070

Title:

A Literature Review on the Mechanism of Action of Sulphur and Nitrogen Mustard

Descriptive Note:

Technical rept.

Corporate Author:

MATERIALS RESEARCH LABS ASCOT VALE (AUSTRALIA)

Personal Author(s):

Report Date:

1989-07-01

Pagination or Media Count:

46.0

Abstract:

The literature describing the mechanism of action of sulphur and nitrogen mustard is reviewed. The conclusion drawn is that the available evidence suggests that DNA is the most important molecular target of these compounds. However, the final outcome of poisoning is modulated by other factors such as DNA repair, glutathione levels and drug transport.

Subject Categories:

  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE