Accession Number:

ADA214442

Title:

An Experimental Brain Missile Wound: Ascertaining Pathophysiology and evaluating Treatments to Lower Mortality and Morbidity

Descriptive Note:

Annual rept. 15 Apr 1987-14 Apr 1988

Corporate Author:

LOUISIANA STATE UNIV MEDICAL CENTER NEWORLEANS

Report Date:

1989-04-27

Pagination or Media Count:

162.0

Abstract:

We evaluated mechanical and chemical regulation of cerebral blood flow CBF following a missile wound to the brain in pentobarbital anesthetized cats. Blood flow was measured by microspheres in more than 25 brain areas including brain immediately adjacent to the missile wound track. After wounding both mechanical and chemical regulation of CBF were greatly impaired. Brain about the missile track was most severely affected. Once ischemic from hemorrhagic hypotension, the wounded brain could not be refused despite restoration of mean arterial blood pressure. Brain wounded animals thus exhibited refusion failure. Following wounding, test animals demonstrated very substantial, but brief, increases in plasma catecholamines. After brain wounding, animals had significant decrements in behavior which gradually recovered up to 30-45 days post-wounding. Some post-wounding defects persisted permanently. We have perfected a model to test drugs to try and improve neurologic recovery after brain wounding.

Subject Categories:

  • Weapons Effects (Biological)

Distribution Statement:

APPROVED FOR PUBLIC RELEASE