Acute Dermal Toxicity of Nitrosoguanidine in Rabbits
Institute rept. 24 Oct-12 Nov 1985
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
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The acute dermal toxicity of nitrosoguanidine, was evaluated in five male and five female New Zealand White rabbits. Nitrosoguanidine 2gkg was applied topically to the clipped dorsal skin surface under a semi-occlusive wrap for 24 hours. There was no evidence of systemic toxicity or death. Nine of the rabbits exhibited slight to moderate erythema after wrap removal and all had cleared by 24 hours. Slight erythema was also observed in 3 rabbits 48-72 hours after wrap removal. These data indicate that nitrosoguanidine does not produce systemic toxicity when administered by 24-hour topical application at a limit dose of 2 gkg. Keywords Triple base propellants Acute dermal toxicity Nitrosoguanidine Rabbit Mammalian toxicology Nitroguanidine.