Accession Number:

ADA214314

Title:

Acute Dermal Toxicity of Nitrosoguanidine in Rabbits

Descriptive Note:

Institute rept. 24 Oct-12 Nov 1985

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Report Date:

1989-09-01

Pagination or Media Count:

27.0

Abstract:

The acute dermal toxicity of nitrosoguanidine, was evaluated in five male and five female New Zealand White rabbits. Nitrosoguanidine 2gkg was applied topically to the clipped dorsal skin surface under a semi-occlusive wrap for 24 hours. There was no evidence of systemic toxicity or death. Nine of the rabbits exhibited slight to moderate erythema after wrap removal and all had cleared by 24 hours. Slight erythema was also observed in 3 rabbits 48-72 hours after wrap removal. These data indicate that nitrosoguanidine does not produce systemic toxicity when administered by 24-hour topical application at a limit dose of 2 gkg. Keywords Triple base propellants Acute dermal toxicity Nitrosoguanidine Rabbit Mammalian toxicology Nitroguanidine.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE