Accession Number:

ADA214313

Title:

Acute Oral Toxicity of Nitrosoguanidine in ICR Mice

Descriptive Note:

Institute rept. 17 Dec 1985-9 Jan 1986

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Report Date:

1989-09-01

Pagination or Media Count:

30.0

Abstract:

The acute oral toxicity of nitrosoguanidine was determined in male and female ICR mice by using the oral gavage single-dose method. The median lethal dose was greater than a limit dose of 5000 mgkg. Clinical signs observed were yellow perianal stains in 2 to 5 males and irritability in 1 of 6 females. These signs were minimal in both severity and duration. According to the classification scheme of Hodge and Sterner, these results place nitrosoguanidine in the practically nontoxic class of chemicals. Keywords Triple base propellants Acute oral toxicity Nitrosoguanidine Mammalian toxicology Mouse Propellants Nitroguanidine kt

Subject Categories:

  • Toxicology
  • Ammunition and Explosives

Distribution Statement:

APPROVED FOR PUBLIC RELEASE