Accession Number:

ADA214312

Title:

Acute Oral Toxicity of Nitrosoguanidine in Sprague-Dawley Rats

Descriptive Note:

Institute rept. 12 Nov-3 Dec 1985

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Report Date:

1989-09-01

Pagination or Media Count:

30.0

Abstract:

The acute oral toxicity of nitrosoguanidine was determined in male and female Sprague-Dawley rats by using the oral gavage single-dose method. The median lethal dose for both male and female Sprague-Dawley rats was greater than 5000 mgkg. Major clinical signs were red nasal staining, yellow perianal staining, irritability, diarrhea, ataxia, and inactivity. These signs were minimal in severity and occurred primarily during the first 24 hours after dosing. According to the classification scheme of Hodge and Sterner, these results place nitrosoguanidine in the practically non-toxic class. Keywords Triple base propellants Mammalian Toxicology Rat Munitions Nitroguanidine. kt

Subject Categories:

  • Toxicology
  • Ammunition and Explosives

Distribution Statement:

APPROVED FOR PUBLIC RELEASE