Accession Number:

ADA214264

Title:

Primary Ocular Irritation Potential of Nitrosoguanidine in Male Rabbits

Descriptive Note:

Institute rept. 10 Oct-15 Nov 1985

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s):

Report Date:

1989-09-01

Pagination or Media Count:

30.0

Abstract:

The potential for nitrosoguanidine to produce primary eye irritation was evaluated in male New Zealand White rabbits by using a modified Draize method. Slight conjunctival vasodilation indicative of mild inflammation was the predominant response observed. Slight iridial hyperemia was noted in one animal and one animal had a small fluorescein-staining area in the cornea. The results indicate that nitrosoguanidine is not a primary ocular irritant under conditions of this study. Keywords Triple base propellants Nitrosoguanidine Ocular irritation Mammalian toxicology Rabbit Munitions Propellants Nitroquanidine.

Subject Categories:

  • Toxicology
  • Ammunition and Explosives

Distribution Statement:

APPROVED FOR PUBLIC RELEASE