Primary Ocular Irritation Potential of Nitrosoguanidine in Male Rabbits
Institute rept. 10 Oct-15 Nov 1985
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
Pagination or Media Count:
The potential for nitrosoguanidine to produce primary eye irritation was evaluated in male New Zealand White rabbits by using a modified Draize method. Slight conjunctival vasodilation indicative of mild inflammation was the predominant response observed. Slight iridial hyperemia was noted in one animal and one animal had a small fluorescein-staining area in the cornea. The results indicate that nitrosoguanidine is not a primary ocular irritant under conditions of this study. Keywords Triple base propellants Nitrosoguanidine Ocular irritation Mammalian toxicology Rabbit Munitions Propellants Nitroquanidine.
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