Effect of Root-Surface Modification of Human Teeth on Adherence of Fibronectin
Research progress rept.
NAVAL DENTAL RESEARCH INST GREAT LAKES IL
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Fibronectin FN is a promising agent in periodontal disease therapy for facilitating reattachment of connective tissue to human tooth-root surfaces. This study examined the influence of various surface treatments on promoting or hindering FN adherence to tooth roots. Rectangular sections of planed and non- planed tooth-root surfaces were acid-demineralized or incubated with collagenase. The tooth-root sections were treated with tritiated FN and its adherence was determined by liquid scintillation counting. The level of FN adherence was highest for non-planed acid-demineralized sections, and lowest for planed-only sections. This adherence varied with FN concentration and duration of contact for non-planed sections, but varied only with duration of contact for planed sections. Collagenase significantly reduced FN adherence to non-planed or planed acid-demineralized sections, but not to planed-only sections. These effects were attributed to tooth-root collagen, which can strongly bind FN. Keywords Fibronectin Root-surface Root-planing Demineralization Collagen Collagenase.
- Medicine and Medical Research