Accession Number:

ADA214029

Title:

Advanced Biosensors for Amino Acid Detection. Phase 1

Descriptive Note:

Rept. for 1-31 Oct 1989

Corporate Author:

ELTRON RESEARCH INC AURORA IL

Personal Author(s):

Report Date:

1989-10-31

Pagination or Media Count:

11.0

Abstract:

Reported here is work directed towards characterizing an advanced biosensor technology compatible for the real-time indirect optical detection of amino acids as typified by e-phen-ylalanine, e-doA, E-TRYPTOPHAN AND RELATED COMPOUNDS. The technical strategy involves the indirect optical detection of amines and amino acids by monitoring changes induced in the visible spectra of immobilized chromagenic acyclic polyether host molecules to which the amine or amino acid becomes associated. Syntheses are currently proceeding for preparation of chromagenic acyclic polyether host molecules into which selected amino acids will become incorporated, resulting in induced color changes, detectable when these molecular species are immobilized onto a fiber optic. Design and fabrication of synchronous sample-and-hold circuitry for detection of small optical changes from the fiber optic has largely been completed.

Subject Categories:

  • Biochemistry
  • Organic Chemistry
  • Fiber Optics and Integrated Optics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE