Accession Number:

ADA214006

Title:

Treatment of Laser Induced Retinal Injuries

Descriptive Note:

Midterm rept. 30 Sep 1987-31 Mar 1989

Corporate Author:

TEL-AVIV UNIV (ISRAEL)

Personal Author(s):

• Belkin, Michael
• Naveh, N.

Report Date:

1989-06-21

Pagination or Media Count:

29.0

Abstract:

Previously we have shown that the ocular response to laser-induced ocular injury is characterized by an enhancement in arachidonic acid metabolism and that steroid treatment curtailed this response. In the present study we investigated the involvement of leukotrienes B4 LTB4 and the following parameters were studied LTB4 production by the retinachoroid, its accumulation in the vitreous, and changes in vitreal protein levels. The effect of an antileukotriene drug on the severity of the ocular inflammatory response was also studied. Our finding that the ocular response to laser-induced retinal injury involves an enhanced leukotriene B4 response, might be responsible for edema formation and accumulation of various toxic substances in the vitreous, with resultant immediate incapacitation of the affected individuals. Treatment to reduce leukotriene production might attenuate vision reduction. Keywords Vitreal protein levels Neodymium YAG laser Leukotriene B4 Blood retinal barrier RA III.

Descriptors:

• *THERAPY
• *RETINA
• *WOUNDS AND INJURIES
• *LASER DAMAGE
• METABOLISM
• REDUCTION
• RESPONSE
• BARRIERS
• VISION
• EYE
• RESPONSE(BIOLOGY)
• ACCUMULATION
• NEODYMIUM
• INFLAMMATION
• BLOOD
• INCAPACITATION
• FATTY ACIDS
• STEROIDS
• LASERS
• PROTEINS
• EDEMA
• YAG LASERS
• TOXICITY

Subject Categories:

• Anatomy and Physiology
• Pharmacology
• Lasers and Masers

Distribution Statement:

APPROVED FOR PUBLIC RELEASE