Accession Number:

ADA210872

Title:

Effect of Glucocorticoids and Catecholamiens on Macrophage Antimicrobial Activity

Descriptive Note:

Annual rept. May 1988-Jul 1989

Corporate Author:

MEDICAL COLL OF PENNSYLVANIA PHILADELPHIA

Personal Author(s):

Report Date:

1989-07-31

Pagination or Media Count:

16.0

Abstract:

The effects of stress hormones on antibacterial and antiviral functions of resident peritoneal macrophages MO were determined. All studies were performed using a serum-free, chemically defined, medium, which eliminates complications which may arise as the result of hormone levels in fetal bovine serum. Restriction of herpes simplex virus type 1 HSV-1 by resident peritoneal macrophages MO was essentially unaffected by the glucocorticoids, catecholamines, or isoproterenol. Phagocytosis of heat killed yeast Streptomyces cerevasiae was, however, inhibited by both dexamethose and corticosterone, but not by epinephrine or isoproterenol. The number of yeast phagocytosed per MO was inhibited by corticosterone in a dose dependent fashion. Killing of Listeria monocytogenes by resident peritoneal MO was not affected by the glucocorticoids. However, killing of L. monocytogenes by IFN or TNFIFN activated MO in vitro activation appeared to be enhanced by dexamethasone. Keywords Antiherpetics Antiviral agents Macrophages Stress Stress hormones Glucocorticoids Dexamethasone Corticosterone Catecholamines Epinephrine Isoproterenol Herpes simplex virus Listeria monocytogenes.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE