Accession Number:

ADA210639

Title:

Topical Hazard Evaluation Program (THEP) Assessment of the Relative Toxicity of Candidate Insect Propellents AI3-38306, AI3-38315, AI3-38530, AI3- 39041, AI3-39076, AI3-39077, AI3-39078, AI3-39085, U.S. Department of Agricultural Proprietary Chemicals Study Numbers, 75-51-0623-89, 75-51-0624-89, 75-51-0625-89, 75-51-0626-89, 75-51-0627-89, 75-51-0628-89, 75-51-0629-89, 75- 510630-89

Descriptive Note:

Study rept.

Corporate Author:

ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD

Personal Author(s):

Report Date:

1989-06-01

Pagination or Media Count:

18.0

Abstract:

The purpose of the Topical Hazard Evaluation Program THEP is to investigate relevant health endpoints of proposed insect repellent chemicals. Data from these studies are used to recommend the course of further entomological and toxicological evaluations with subject chemicals. The results from the current animal sensitization studies showed that two of the eight test compounds AI3-39076 and AI3-39077 have some potential for causing an allergic response in man. A positive result from a sensitization test is a prime basis for rejecting a material as a topical insect repellent. The results from the overall battery of biological tests showed that the candidate inset repellents AI3-38530, AI3-39041, and AI3-39078 produced relatively unremarkable toxicological responses.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE