Accession Number:

ADA210416

Title:

Hemostatic Activity of Chitosan in Wound Management

Descriptive Note:

Quarterly progress rept. no. 2, 1 Apr-30 Jun 1989

Corporate Author:

MINNESOTA MINING AND MFG CO ST PAUL WOUND MANAGEMENT PRODUCTS LAB

Personal Author(s):

Report Date:

1989-06-30

Pagination or Media Count:

8.0

Abstract:

Research has continued on the preparation of a hemostatic agent in the form of a lyophilized sponge composed of chitosan glutamate and collagen. Characterization of the chitosan glutamate raw material has progressed levels of metal and amino acid contamination were determined. Work was also initiated on the vitro degradation of chitosan glutamate by lysozyme. Over 25 sample compositions of various chitosan glutamatecollagen sponges were evaluated for wet and dry strength, handling characteristics, and hemostatic activity in a rat bleeding sagittal sinus model. From these samples, two compositions were indentified for further testing. Semex Medical was identified as the manufacturer of the sponge samples. Keywords Collagen Chitosan glutamate Hemostatic agents Hemostatic sponges Medical supplies.

Subject Categories:

  • Medical Facilities, Equipment and Supplies
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE