Accession Number:

ADA210384

Title:

Spatial Relationships between Drug Binding Sites on the Surface of the Acetylcholine Receptor

Descriptive Note:

Annual rept.

Corporate Author:

CALIFORNIA UNIV RIVERSIDE

Personal Author(s):

Report Date:

1987-10-15

Pagination or Media Count:

108.0

Abstract:

This report is divided into three sections dealing with the development and use of fluorescent probes of the nicotinic acetylcholine receptor AcChR. Section I summarized the purification and characterization of four mono-fluorescein cobra a-toxin derivatives. Section II deals with the use of the about derivatives to define the approximate orientation of cobra a-toxin on the acetylcholine receptor. Section III summarizes our measurements of the intersite distances between the binding sites for acetylcholine and phencyclidine on the nicotinic acetylcholine receptor.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE