Control of Synthetic Peptide Tertiary Structure
Progress rept. Feb-Jul 1989
WASHINGTON UNIV SEATTLE DEPT OF CHEMISTRY
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The proposed research seeks to design and synthesize large organic molecules possessing precisely defined geometric shapes, A capability which will make possible the design of catalysis and receptors. The approach entails the design of unnatural amino acids which, when incorporated into peptides, will enforce tertiary structure on the overall molecule. Methods are also suggested whereby transiently stable noncovalent complexes of peptides might be permanently stabilized by covalent crosslinking, leading to the concept of self-assembly of large, highly ordered organic molecules. The additional possibility of assembling large structures from smaller pieces by incorporation of temporary functionality which will initially spatially orient small pieces prior to covalent assembly is suggested, a concept termed directed assembly. Keywords Molecular structure Peptide secondary structure Molecular design Circular dichroism Alpha-helix Protein thermostabilization.
- Genetic Engineering and Molecular Biology
- Organic Chemistry