Accession Number:

ADA210339

Title:

Control of Synthetic Peptide Tertiary Structure

Descriptive Note:

Progress rept. Feb-Jul 1989

Corporate Author:

WASHINGTON UNIV SEATTLE DEPT OF CHEMISTRY

Personal Author(s):

• Hopkins, Paul B.

Report Date:

1989-07-01

Pagination or Media Count:

3.0

Abstract:

The proposed research seeks to design and synthesize large organic molecules possessing precisely defined geometric shapes, A capability which will make possible the design of catalysis and receptors. The approach entails the design of unnatural amino acids which, when incorporated into peptides, will enforce tertiary structure on the overall molecule. Methods are also suggested whereby transiently stable noncovalent complexes of peptides might be permanently stabilized by covalent crosslinking, leading to the concept of self-assembly of large, highly ordered organic molecules. The additional possibility of assembling large structures from smaller pieces by incorporation of temporary functionality which will initially spatially orient small pieces prior to covalent assembly is suggested, a concept termed directed assembly. Keywords Molecular structure Peptide secondary structure Molecular design Circular dichroism Alpha-helix Protein thermostabilization.

Descriptors:

• *AMINO ACIDS
• *MOLECULAR STRUCTURE
• *PEPTIDES
• PROTEINS
• COVALENT BONDS
• SYNTHESIS(CHEMISTRY)
• STRUCTURES
• CROSSLINKING(CHEMISTRY)
• GEOMETRIC FORMS
• ORGANIC COMPOUNDS
• CATALYSIS
• ASSEMBLY
• CIRCULAR
• DICHROISM
• SECONDARY
• MOLECULES
• STABILIZATION
• SYNTHESIS

Subject Categories:

• Genetic Engineering and Molecular Biology
• Organic Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE