Accession Number:

ADA210295

Title:

Development of Elastomeric Polypeptide Biomaterials

Descriptive Note:

Annual rept. 1 Jun 1988-31 May 1989

Corporate Author:

ALABAMA UNIV IN BIRMINGHAM LAB OF MOLECULAR BIOPHYSICS

Report Date:

1989-07-01

Pagination or Media Count:

115.0

Abstract:

The purpose of this research was to design, prepare and characterize novel elastomeric polymers comprised of repeating peptide sequences, primarily the elastin pentamer and analogs of it alone and combined with repeating related hexapeptides andor tetrapeptides. The purpose is to develop polymers with different elastic moduli and increased extension limits, polymers with different temperature ranges for their inverse temperature transitions over which elastomeric force dramatically changes, polymers in which different intensities and frequencies of their dielectric relaxations and polymers with wider temperature ranges over which they function as nearly ideal elastomers. In the elastomer design, the dominant repeat units will be pentamers and tetramers. Hexamers and alanine-rich, lysine-containing cross-linking sequences will be used to fine-tune properties. Keywords Polymer chemistry Biomaterials.

Subject Categories:

  • Biochemistry
  • Polymer Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE