Accession Number:

ADA210155

Title:

Plasma Volume Expansion in Rats: Effects on Thermoregulation and Exercise

Descriptive Note:

Journal article

Corporate Author:

ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Report Date:

1989-01-01

Pagination or Media Count:

7.0

Abstract:

Administration of polyethylene glycol PEG, intraperitioneal, 3 ml, 30 solution to adult male rats 300 g resulted in an approx. 20 increment in plasma volume PV 24 H after PEG injection. When these animals were exercised 9.14 mmin, level treadmill in a warm 30 C, 30-40 relative humidity environment, their mean endurance was increased from 67.9 saline-treated controls CONT to 93.6 min P 0.01. Total water loss was increased from 12.2 CONT to 17.2 g PEG, P 0.01. Atropine administration ATR, 200 micrograms kg, tail vein significantly P0.05 reduced both the endurance and the salivary water loss of CONT and PEG-treated rats, where as it increased the heating rate P 0.01 of both groups. PEG treatment reduced P0.01 the hematocrit and circulating protein levels both before and subsequent to exercise in the warm environment. Clinical chemical indexes of heatexercise injury were generally unaffected by pharmacological intervention, whereas clinical chemical response to exercise were related to the endurance time each group. We concluded that expansion of PV by PEG provided significant beneficial in warm environment. Keywords Reprints.

Subject Categories:

  • Stress Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE