Accession Number:

ADA210040

Title:

Cloning of Plasmodium yoelii Genes Expressing Three Different Sporozoite-Specific Antigens

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Personal Author(s):

• Wortman, A.
• Rogers, P.
• Charoenvit, Y.
• McDermott, A.
• Leef, M.
• Sedegah, M.
• Beaudoin, R. L.

Report Date:

1989-01-01

Pagination or Media Count:

6.0

Abstract:

Despite the rapid advances in the development of a recombinant vaccine against Plasmodium falciparum sporozoites, there is still an urgent need for a reliable rodent model to carry out complex vaccine protocols difficult to perform in primates or man. The purpose of this research was to clone the P. yoelii genes coding for sporozoite antigens that have potential as vaccine candidates in a rodent model. Keywords Sporozoite antigens Plasmodium yoelii Recombinant DNA Monoclonal antibodies Rodent malaria Reprints.

Descriptors:

• *VACCINES
• *PLASMODIUM
• *CLONES
• *GENETIC ENGINEERING
• GENES
• PRIMATES
• MONOCLONAL ANTIBODIES
• MALARIA
• SPOROZOITES
• RODENTS
• PLASMODIUM FALCIPARUM
• ANTIGENS
• RELIABILITY
• CODING
• DEOXYRIBONUCLEIC ACIDS
• REPRINTS
• MODELS

Subject Categories:

• Genetic Engineering and Molecular Biology
• Medicine and Medical Research
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE