Accession Number:

ADA210035

Title:

Immune Response Gene Regulation of Immunity to Plasmodium Berghei Sporozoites and Circumsporozoite Protein Vaccines

Descriptive Note:

Journal article

Corporate Author:

NAVAL MEDICAL RESEARCH INST BETHESDA MD

Personal Author(s):

• Hoffman, Stephen L.
• Berzofsky, Jay A.
• Isenbarger, Daniel
• Zeltser, Elana
• Majarian, William R.
• Gross, Mitchell
• Ballou, W. R.

Report Date:

1989-05-15

Pagination or Media Count:

5.0

Abstract:

We conducted a series of experiments to define Ir gene regulation of the immune response to Plasmodium berghei sporozoites and circumsporozoite CS protein derived subunit vaccines. The studies demonstrated that there is no apparent genetic restriction of the capacity to develop protective immunity against a large sporozoite challenge after immunization with irradiation- attenuated P. berghei sporozoites. The results support the development of full length human CS protein vaccines to take advantage of all potential T epitopes on this protein. Reprints.

Descriptors:

• *SPOROZOITES
• *VACCINES
• *GENETICS
• *IMMUNITY
• *PLASMODIUM BERGHEI
• REGULATIONS
• IMMUNIZATION
• IMMUNOLOGY
• RESPONSE(BIOLOGY)
• GENES
• PROTEINS
• REPRINTS

Subject Categories:

• Genetic Engineering and Molecular Biology
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE