Accession Number:

ADA210007

Title:

Perfluorodecanoic Acid and Lipid Metabolism in the Rat

Descriptive Note:

Annual rept. Jun 1988-Jun 1989

Corporate Author:

WISCONSIN UNIV-MADISON SCHOOL OF PHARMACY

Report Date:

1989-05-25

Pagination or Media Count:

17.0

Abstract:

Derivatives of perfluorosulfonic and perfluorocarboxylic acids have been used in a number of industrial applications as lubricants, plasticizers, writing agents and corrosions inhibitors. Aqueous film-forming foams, used as fire extinguishants, contain mixtures of hydrocarbon and fluorocarbon surfactants derivatized fatty acids due to their superior surface-active properties. Studies on the effects of perfluorodecanoic acid PFDA on lipid metabolism in the rat after a single intraperitoneal dose 20,40, 80 mgkg were completed. Because PFDA treatment causes a dose-related reduction in feed intake, the response of vehicle-treated rats pair-fed to those receiving PFDA was monitored to distinguish direct effects of the perfluorinated fatty acid from those secondary to hypophagia. A reduction in the carcass content of lipid phosphorus phospholipid and free cholesterol in rats treated with PFDA appeared to be consequent to hypophagia, as the pair-fed animals exhibited the same attenuation. PFDA-treated rats were found to have a higher concentrations of triacylglycerols than their vehicle-treated, pair-fed counterparts. It appears PFDA treatment results in the diversion of fatty acids from oxidations towards esterifcation in the liver. Reprints.

Subject Categories:

  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE