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Accession Number:
ADA210007
Title:
Perfluorodecanoic Acid and Lipid Metabolism in the Rat
Descriptive Note:
Annual rept. Jun 1988-Jun 1989
Corporate Author:
WISCONSIN UNIV-MADISON SCHOOL OF PHARMACY
Report Date:
1989-05-25
Pagination or Media Count:
17.0
Abstract:
Derivatives of perfluorosulfonic and perfluorocarboxylic acids have been used in a number of industrial applications as lubricants, plasticizers, writing agents and corrosions inhibitors. Aqueous film-forming foams, used as fire extinguishants, contain mixtures of hydrocarbon and fluorocarbon surfactants derivatized fatty acids due to their superior surface-active properties. Studies on the effects of perfluorodecanoic acid PFDA on lipid metabolism in the rat after a single intraperitoneal dose 20,40, 80 mgkg were completed. Because PFDA treatment causes a dose-related reduction in feed intake, the response of vehicle-treated rats pair-fed to those receiving PFDA was monitored to distinguish direct effects of the perfluorinated fatty acid from those secondary to hypophagia. A reduction in the carcass content of lipid phosphorus phospholipid and free cholesterol in rats treated with PFDA appeared to be consequent to hypophagia, as the pair-fed animals exhibited the same attenuation. PFDA-treated rats were found to have a higher concentrations of triacylglycerols than their vehicle-treated, pair-fed counterparts. It appears PFDA treatment results in the diversion of fatty acids from oxidations towards esterifcation in the liver. Reprints.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE
