Accession Number:

ADA209868

Title:

24-Hour Mean Plasma Hormone Levels in Men with Coronary Heart Disease

Descriptive Note:

Final rept. 1 May 1978-30 Apr 1979

Corporate Author:

MONTEFIORE HOSPITAL AND MEDICAL CENTER BRONX NY

Personal Author(s):

Report Date:

1979-07-26

Pagination or Media Count:

17.0

Abstract:

Effort has involved the plasma concentrations of 14 hormones in 10 rigorously selected younger men who have recovered well from a myocardial infarction, and in 34 suitable controls. Concentrations of 11 hormones were normal. Concentrations of 3 abnormal estrone was elevated from the normal average, dehydroisoandrosterone was elevated from normal, triiodothyronine was decreased from normal. All three of these abnormalities are in the direction of femaleness, i.e. women normally have higher levels of estrone and dehydroisoandrosterone and lower levels of Ttiodothyronine than men. Two of the abnormalities, those of estrone and dehydroisoandrosterone are also found in obese men. A discriminant composed of all 3 of the individually abnormal hormones yields nearly total separation of the post-infarct group from normal controls there is only 1 overlap. 24 Hour urine analyses were accomplished on 6 men with abnormal and 21 men with normal coronary arteriograms. Total androgen metabolites excretion was lower in the abnormals than in the normals, and the excretion of androsterone glucuronide was markedly lower. Keywords Hormones Cardiac patients.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE