Accession Number:

ADA209751

Title:

Atropine and Scopolamine as Adjuncts to Physostigmine in Exercising Rats

Descriptive Note:

Corporate Author:

ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA

Personal Author(s):

Report Date:

1989-05-01

Pagination or Media Count:

7.0

Abstract:

Previous work demonstrated a dose-related physostigmine PH-induced cholinesterase inhibition and dose-response performance decrements in exercising rats. In the present work, the optimal dose of atropine AT and scopolamine S as adjuncts to PH administration to attenuate the PH-induced performance decrements were determined. Experimental rats received via tail vein 100, 200, or 400 microgramskg of AT prior to 200 microgramskg of PH or 4, 8, 16, or 32 microgramskg of S prior to 200 microgramskg of PH controls received 2 saline injections. Fifteen min after drug administration, rats were run to exhaustion on a motor driven treadmill. Run time and heating rate rate of rise of core temperature for the AT experiment are recorded. These data indicate that 200 microgramskg of AT or 8-16 microgramskg of S are the optimal doses of each drug for use as adjuncts to relieve the decremental effects of PH in exercising rats. The improvement in performance seen with AT and S adjuncts to PH may be primarily due to muscarinic cholinergic blockade.

Subject Categories:

  • Stress Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE