Aprohrne and Scopolamine: Metabolic and Clinical Chemical Effects during Exercise
ARMY RESEARCH INST OF ENVIRONMENTAL MEDICINE NATICK MA
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Adult, male rats were pretreated with intravenously administered saline C, Control, low dosage scopolamine LS, 18.1, high dosage scopolamine HS, low dosage aprohrne LA, or high dosage aprophen HA 15 min prior to exercise in a warm environment. A small blood sample was removed from a permanently implanted jugular catheter immediately prior to drug administration and subsequent to completion of exercise. HS significantly reduced endurance capacity and increased heating rate. While endurance was slightly attenuated in HA and heating rate was minimally increased, the effects on neither variable achieved statistical significance. While circulating sodium levels in all groups were generally unaffected by pharmacological intervention or exercise, the mean plasma potassium concentration of HS-treated rats was significantly greater post-exercise than comparable levels in LS, LA, and HA-treated animals. Despite the reduced endurance capacity of the HS group, this was the only treatment group that manifested a significant pre to post exercise elevation in circulating lactate levels. These results indicated that of the drugs and doses evaluated, only the high dosage scopolamine had marked effects on several circulating indices of heatexercise injury as well as performance. Significant elevations in post-exercise plasma lactate levels in this group indicate that HS may be having a metabolic effect impacting upon heating rate and physical performance.
- *PARASYMPATHOLYTIC AGENTS
- PHYSIOLOGICAL EFFECTS
- WOUNDS AND INJURIES
- HEAT BALANCE