Accession Number:

ADA209589

Title:

The Determination of the Acute and Repeated Oral Toxicity of Halocarbon Oil, Series 27-S

Descriptive Note:

Interim rept. Dec 86-Nov 87

Corporate Author:

NORTHROP SERVICES INC - ENVIRONMENTAL SCIENCES DAYTON OH

Report Date:

1989-02-01

Pagination or Media Count:

61.0

Abstract:

Halocarbon 27-S HC 27-S, a polymer of chlorotrifluoroethylene CTFE, is used as a lubricating oil for pumps in hyperbaric chambers. Although monomeric CTFE has been shown to produce renal lesions in rats, the toxicity of CTFE polymers has not been investigated. Following a single dose of 5 g HC 27-S, no signs of toxicity were noted and no lesions observed at sacrifice 14 days following treatment. To assess the toxicity of repeated exposure to HC 27-S, three groups n5 of male and female rats were dosed with 2.5 g HC 27-Skg for 7 or 21 consecutive days. Groups were sacrificed at 7, 21, and 35 days after the initial dose. Decreased water consumption and urine output were apparent in all test groups. Significant increase in fluoride excretion was noted in 24-hr urine samples collected periodically during the study. The increased fluoride burden in treated animals appeared sufficient to alter bone calciumphosphate ratios in male but not female rats. Increased liver and kidney weights were observed in all treated rats on all assessment days. Gross liver enlargement and hepatocellular cytomegaly indicated that the liver is probably the primary target organ following repeated administration of HC 27-S. Keywords Lubricants, Toxicity, Bone, Calciumphosphate ratio, Chlorotrifluoroethylene, Fluoride, Halodarbon 27-S, Hepatocellular cytomegaly.

Subject Categories:

  • Biochemistry
  • Toxicology
  • Lubricants and Hydraulic Fluids

Distribution Statement:

APPROVED FOR PUBLIC RELEASE