Quantitative Classification of Known Protein Structures
Annual rept. Jul 1988-Jun 1989
ROCHESTER UNIV NY SCHOOL OF MEDICINE AND DENTISTRY
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Mathematical methods have been developed for comparing the structures of proteins of arbitrary different molecular weight. A data base of structures representative of the entire Brookhaven Protein Data Bank has been assembled, containing 123 protein structures. This data base has been analyzed, using the methods developed, to determine the large-scale and local structure of the proteinome. Evidence exists for the existence of two distinct types of Beta- sheetbarrel proteins, and several types of mainly alpha-helical structures. Studies as a function of structural length scale and resolution are possible with the methods developed herein. Keywords Molecular structure.
- Genetic Engineering and Molecular Biology
- Operations Research