Evaluation of Euthymic Hairless Guinea Pigs (Crl:IAF(HA)BR) as an Animal Model for Vesicant Injury
Final rept. Aug 88-Jan 89
ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD
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Euthymic hairless guinea pigs were compared to normal haired guinea pigs to determine whether the hairless guinea pig is a suitable animal model for studying sulfur mustard HD induced vesication of skin. Neat HD was applied to the skin for 30 minutes, and the exposed skin was examined at 24 andor 48 hours post-exposure for gross, histopathologic, andor ultrastructural lesions. The hairless guinea pig proved to be a superior animal model compared to the haired guinea pig because it was more sensitive to HD, the lesions were more readily scored, and the animal was much more convenient to use. Keywords Guinea pigs Hairless guinea pigs Mustard Vesicant.
- Weapons Effects (Biological)
- Chemical, Biological and Radiological Warfare