The Effect of Housing (Number of Mice/Cage) on Immunologic Competency
Final rept. 15 Jul 1987-30 Sep 1988
PITTSBURGH UNIV PA DIV OF CLINICAL IMMUNOPATHOLOGY
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This project evaluated the effect of housing 1 or 5 mice in identical sized cages on immunologic function. We have found that the C3HHeJ male mouse, when placed from group housing to 1 animal housed per cage, has enhanced T cell related immune function in comparison to mice housed per cage. Female C3H mice do not show this effect. The effect is present approximately 10 days after being placed into a single cage and lasts approximately 3-4 weeks. The altered immune reactivity is not related to corticosterone levels. Other cytokines, including IL-1 and macrophage colony stimulating factor are also produced in higher concentrations in individually housed mice. Bone marrow hematopoietic cell activity is greater in individually housed mice. Animals housed 1 per cage are significantly more resistant to infection with Candida albicans than animals housed 5 per cage. The time course of the development of enhanced resistance is similar to other immunologic parameters measured.
- Medicine and Medical Research
- Stress Physiology