Accession Number:

ADA207823

Title:

The Effect of Housing (Number of Mice/Cage) on Immunologic Competency

Descriptive Note:

Final rept. 15 Jul 1987-30 Sep 1988

Corporate Author:

PITTSBURGH UNIV PA DIV OF CLINICAL IMMUNOPATHOLOGY

Personal Author(s):

Report Date:

1989-05-01

Pagination or Media Count:

6.0

Abstract:

This project evaluated the effect of housing 1 or 5 mice in identical sized cages on immunologic function. We have found that the C3HHeJ male mouse, when placed from group housing to 1 animal housed per cage, has enhanced T cell related immune function in comparison to mice housed per cage. Female C3H mice do not show this effect. The effect is present approximately 10 days after being placed into a single cage and lasts approximately 3-4 weeks. The altered immune reactivity is not related to corticosterone levels. Other cytokines, including IL-1 and macrophage colony stimulating factor are also produced in higher concentrations in individually housed mice. Bone marrow hematopoietic cell activity is greater in individually housed mice. Animals housed 1 per cage are significantly more resistant to infection with Candida albicans than animals housed 5 per cage. The time course of the development of enhanced resistance is similar to other immunologic parameters measured.

Subject Categories:

  • Medicine and Medical Research
  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE