Pathophysiology of Peptide Toxins of Microcystis aeruginosa and Amanita phalloides
Final rept. 1 Apr 1985-30 Jun 1986
BROOKHAVEN NATIONAL LAB UPTON NY
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Studies focused on the pathophysiology of the cyclic peptide toxin from M. aeruginosa and prophylaxis against it. The critical role of the liver as a target organ for the toxin and site of prophylaxis was established. The particular liver cell type critical to the toxin was not established. The most effective protective agents were trypan red and cyclosporine. The mechanism of action of protection was not established, but the low effective doses for each protective agent suggested great specificity in the mechanism of protection. Keywords Antitoxins, Phytotoxins.