Resuscitation of Conscious Pigs Following Hemorrhage: Oxygen Delivery and Demand during Fixed-Volume Hemorrhage and Resuscitation with 7.5% NaCl in 6% Dextran
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
Pagination or Media Count:
A conscious porcine model was used to investigate the adequacy of 2 delivery relative to O2 demand, initially during a fixed-volume hemorrhage and subsequently after resuscitation with 7.5 NaC16 Dextran 70. Hemorrhage produced a small increase in O2 consumption, severe lactacidemia and a doubling of apparent O2 demand. These effects were attributable to a behavioral compensation periodic bouts of muscle activity which presumably served to improve venous return. Despite enhanced ventilator function, O2 delivery was markedly reduced by hemorrhage, an effect that was due entirely to decrements in cardiac output and hemoglobin level. Resuscitation with 7.5 NaC16 Dextran 70 rectified the disparity between O2 demand, primarily by suppression of demand and secondarily by improvement in delivery.
- Medicine and Medical Research
- Stress Physiology