Accession Number:

ADA207249

Title:

Resuscitation of Conscious Pigs Following Hemorrhage: Blood Gas and Acid-Base Status during Fixed Volume Hemorrhage and Resuscitation with Hypertonic Saline/Dextran

Descriptive Note:

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Report Date:

1989-01-01

Pagination or Media Count:

18.0

Abstract:

Six conscious, chronically instrumented pigs were subjected to a progressive , fixed-volume hemorrhage 37.5 mlkg over 1 h l and subsequent resuscitation with 7.5 NaC16 Dextran 70 4mlkg. Hemorrhage led to increases in arterial PO2, Hboz, plasma lactate base deficit, and mixed venous PC02. It led to decreases in arterial PCO2, plasma bicarbonate, buffer base, and mixed venous P02, Hb02 and pH. These effects were attributable to reduce 02 delivery, lactacidemia, hyperventilation and hemodilution. Resuscitation with hypertonic salinedextran produced an immediate increase in cardiac output and a transfer of venous blood attributes to the arterial circulation. Resuscitation also produced an immediate decrease in arterial buffer base, an effect attributable to hemodilution. Subsequently over 4 h, most variables gradually reverted toward control levels, thereby rectifying the deleterious blood gas and acid-base disturbances produced by server hemorrhage. Keywords partial pressure, carbon dioxide, Oxygen, oxyhemoglobin, sodium chloride.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE