Accession Number:

ADA207247

Title:

Acute Intravenous Toxicity Study of Hypertonic Saline/Dextran 70 (Trade Name) and Constituents in ICR Mice

Descriptive Note:

Rept. for 25 May-28 Jun 1988

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Report Date:

1988-12-01

Pagination or Media Count:

170.0

Abstract:

The acute toxicity following intravenous administration of a proposed new resuscitation fluid, hypertonic salineDextran 70 HSD, was evaluated in male and female ICR mice. Animals were administered a single intravenous dose of HSD, 28 m1kg over a 5-minute period, in an attempt to define its maximum tolerated dose. Equal volumes of each HSD component, 7.5 hypertonic saline HS and 6 Dextran 70 D70 in normal saline, and Ringers lactate RL were also evaluated. Major signs observed in all groups were hunched posture, rough coat, hyperactivity, inactivity, and increased rate andor depth of respiration. Body weights were unaffected by the dosing and no gross or microscopic lesions could be attributed to HSD or its constituents. These data suggest that the maximum tolerated dose of HSD following acute intravenous administration is less than 28 mlkg, and that the toxicity associated with HSD is consistent with the administration of large volumes of hypertonic saline. Since the proposed therapeutic dose of HSD is only 4 mlkg, these findings indicate that there will be minimal adverse effects associated with the therapeutic administration of HSD.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE