Accession Number:

ADA207233

Title:

Acute Oral Toxicity of Diethyleneglycol Dinitrate (DEGDN) in Rats

Descriptive Note:

Rept. for 1 May-5 Jun 1985

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Report Date:

1989-03-01

Pagination or Media Count:

81.0

Abstract:

The acute oral toxicity of the nitrate ester, diethyleneglycol dinitrate DEGDN, was determined in male and female Sprague-Dawley rats by using the oral gavage single-dose method. The median lethal dose MLD was 990.4 or - 30.0 mgkg for male rats and 753.1 or - 35.9 mgkg for female rats. Clinical signs produced by DEGDN included twitching, tremors, hypertonia, squinting, lacrimation, depression of grasping and righting reflexes, jumping, increased startle reflex, ataxia, cyanosis, inactivity, and prostration. The extent of the neurotoxic component of this clinical signs profile suggests that DEGDN possesses additional pharmacological properties than those routinely associated with the nitrate esters. The duration of clinical signs was acute. Most animals were exhibiting signs by 2 hours after dosing and had either died or cleared by 72 hours after dosing. According to the classification scheme of Hodge and Sterner, these results place DEGDN in the slightly toxic class.

Subject Categories:

  • Toxicology
  • Ammunition and Explosives

Distribution Statement:

APPROVED FOR PUBLIC RELEASE