Accession Number:

ADA205208

Title:

Diagnosis and Management of Trichothecene in the Swine Model

Descriptive Note:

Annual rept. (Final) 1 Jul 1985-31 Jan 1988

Corporate Author:

ILLINOIS UNIV AT URBANA

Report Date:

1988-09-01

Pagination or Media Count:

470.0

Abstract:

The efficacy of a variety of approaches for the treatment of iv induced acute T-2 toxicosis was assessed in rats and swine. 1 Oral po superactivated charcoal SAC, intravenous iv, dexamethasone DEX, intraperitoneal ip, methylpredenisolone MPSS, but not ip ascorbic acid, were effective post-toxin therapeutic agents in rats as measured by increases in survival times ST. 2 Pre- and post-toxin iv treatment of rats with po SAC resulted in increased ST and decreased lesion severity in the duodenum, jejunum, and ileum. 3 SAC or Ambersorb resin XE-348F was effective in absorbing T-2 toxin vitro, and in prolonging the STs of rats given lethal 8 mgkg po doses of the toxin followed by po SAC or resin at 1 gkg or less. SAC was a more effective binding agent than the resin. 4 Similarities in pharmacokinetic data for DEX in rats indicated that they may be an acceptable model for humans. Keywords T-2 Toxin, Therapy, Cutaneous therapy, Combination therapy, Drug therapy, Metabolism, Gl Blood flow, Superactivated charcoal, Pathophysiology, Histopathology, Ascorbic acid, Dexamethasone, Dexamethasone pharmackinetics, Methylprednisolone, Ambersorb resin, Diactoxyscirpenol, Dexoynivalenol, Biotransformation, De-epoxidation, Analysis, Hydrolysis, Hydroxylation, Conjugation, Mass spectra, Metabolism.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE