Role of Carbohydrate in Glycoprotein Traffic and Secretion
NAVAL MEDICAL RESEARCH INST BETHESDA MD
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This chapter reviews the evidence that carbohydrate groups may function as markers for intracellular transport and sorting of membrane and secretory glycoproteins in vertebrate cells. The receptor-mediated trafficking to lysosomes of acid hydrolases with oligosaccharide chains containing mannose 6-phosphate residues is the best understood pathway by which proteins translocated into the endoplasmic reticulum are segregated and delivered to their ultimate destination. The 10 chapters in the report focus on Evidence for Intracellular Transport Signals, Oligosaccharide Biosynthesis, Role of Carbohydrate in Protein Solubility, Structure, and Stability, Evidence for Carbohydrate Transport Signals Using Site-Directed Mutagenesis, Mutations That Alter Glycosylation and Glycoprotein Traffic, Tunicamycin and Glycoprotein Traffic, Inhibitors of Oligosaccaride Processing and Glycoprotein Traffic, and Vertebrate Lectins and Glycoprotein Traffic. Reprints.