Accession Number:

ADA202783

Title:

Acute Oral Toxicity of Physostigmine Salicylate in Guinea Pigs

Descriptive Note:

Rept. for 7 Jul-24 Sep 1987

Corporate Author:

LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA

Personal Author(s):

Report Date:

1988-11-01

Pagination or Media Count:

72.0

Abstract:

The acute oral toxicity of physostigmine salicylate was determined in male and female Hartley guinea pigs using the single dose method. The median lethal dose for both male and female guinea pigs was less than 7.1 mgkg. Clinical signs observed were primarily related to changes in behavior such as tremors, hypertonia, irritability, ataxia, and inactivity. Other frequently observed clinical signs included salivation, diarrhea, and lacrimation. The duration of the clinical signs was acute. Most animals were exhibiting signs by 24 hours after dosing and had either died or returned to normal by 72 hours after dosing. According to the classification scheme of Hodge and Sterner, these results place physostigmine salicylate in the highly toxic class. Keywords Acute oral toxicity, Guinea pig, Ra V.

Subject Categories:

  • Toxicology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE