Dermal Sensitization Potential of Diethyleneglycol Dinitrate (DEGDN) in Guinea Pigs
Rept. for 7 Mar-15 Apr 1985
LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA
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The Department of Defense is considering the use of either diethyleneglycol dinitrate DEGDN, triethyleneglycol dinitrate TEGDN, or trimethylolethane trinitrate TMETN as a replacement for nitroglycerin in new propellant formulations. However, considerable gaps in the toxicology data of the compounds were identified during a review of their health effects 1 conducted for the US Army Biomedical Research and Development Laboratory USABRDL. Consequently, USABRDL has tasked the Division of Toxicology, Letterman Army Institute of Research LAIR, to conduct an initial health effects evaluation of the proposed replacement nitrate esters. Keywords Dermal sensitization, Diethyleneglycol dinitrate, DEGDN, Buehler test, Guinea pigs.
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