Accession Number:

ADA201912

Title:

Functional Cardiorespiratory Toxicity Screening of Candidate Antiparasitic Drugs and Antidotes for Chemical Poisons. Study of the Effects of Drugs Upon the Cardiovascular and Respiratory Systems

Descriptive Note:

Annual rept. 1 Nov 1985-31 Oct 1986

Corporate Author:

MEDICAL COLL OF GEORGIA AUGUSTA DEPT OF PHARMACOLOGY AND TOXICOLOGY

Report Date:

1988-06-01

Pagination or Media Count:

74.0

Abstract:

During this past year we have 1. Completed study of the Cardiovascular and Pulmonary Effects of Pyridostigmine Bromide in the Dog Correlation with blood cholinesterase Inhibition. A copy of this report is attached Section I. 2. Written a protocol to study the Effects of Choloroquine and Mefloquine Individually and in Combination Upon Automaticity, Rhythmicity, and Dynamics of the Heart. A copy of this protocol is attached Section II. A range of doses of pyridostigmine were infused intravenously into anesthetized beagle dogs to determine the minimal effective and the maximum tolerated doses upon cardiovascular and pulmonary function and blood cholinesterase Che activity. The 0.5 mgkg dose of pyridostigmine produced a slight 10 fall in tidal volume and airway compliance, a 200 increase in airways resistance, but no change in respiratory rate or minute volume. This dose also produced a 10 fall in heart rate, a small increase in cardiac output 8, stroke volume 20 and pulmonary artery 15 and wedge pressure 2mmHg, and a 35 fall in blood Che activity.Keywords Cardiopulmonary, Pyridostigmine bromide , Compliance, Resistance, Cholinesterase, Chloroquine, Mefloguine, Automaticity, Rhythmicity.

Subject Categories:

  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE