Accession Number:

ADA200922

Title:

Lassa Fever Immune Plasma

Descriptive Note:

Annual rept. 1 Jul 1987-30 Jun 1988

Corporate Author:

COLUMBIA UNIV NEW YORK COLL OF PHYSICIANS AND SURGEONS

Personal Author(s):

Report Date:

1988-07-31

Pagination or Media Count:

22.0

Abstract:

During the year 358 units of Lassa Fever Immune Plasma were obtained by plasmapheresis. Of these, 180 were forwarded to the US Army Medical Research Institute of Infectious Diseases USAMRIID. Most will likely be used there in the production of Lassa Fever Immune Globulin LFIG. LFIG will be a relatively stable product of known potency for the treatment of LF. Attempts to diagnose LF continued. The serological diagnosis of LF is made by seroconversion or a four- fold rise in the titer of indirect fluorescent antibody IFA. Possible LF PLF is diagnosed by an IFS titer of 164 in a patient with an illness compatible with LF. At CLH 32 cases of LF and 11 of PLF were found there were 27 and 25 cases, respectively, at PH. A case of PLF at Kolahun Hospital in the Liberian Northwest and one LF at ELWA hospital near the coast were the first active cases to be identified at these sites. A clinical association of LF with icteric hepatitis, and the impression that LF at PH has been more severe and more contagious recently than in the past deserve further virological study. Keywords Lassa virus, Immunotherapy.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE