Accession Number:

ADA200827

Title:

Release of Multiple Hormones by a Direct Action of Interleukin-1 on Pituitary Cells

Descriptive Note:

Corporate Author:

WALTER REED ARMY INST OF RESEARCH WASHINGTON DC

Report Date:

1987-10-23

Pagination or Media Count:

5.0

Abstract:

Exposure to bacterial endotoxins has long been known to stimulate the release of anterior pituitary hormones administration of endotoxin was at one time a common clinical test of anterior pituitary function. Endotoxin is a potent stimulus for production of the endogenous pyrogenic protein, interleukin- I IL-I, by macrophages and monocytes. The possibility that IL-I has a direct effect on the secretion of hormones by rat pituitary cells in a monolayer culture was investigated. Recombinant human IL-I beta stimulated the secretion of adrenocorticotropic hormone, luteinizing hormone, growth hormone, and thyroid-stimulating hormone. Prolactin secretion by the monolayers was inhibited by similar doses. These concentrations of IL-I are within the range reported for IL-I in serum, suggesting that IL-I generated peripherally by mononuclear immune cells may act directly on anterior pituitary cells to modulate hormone secretion in vivo. Incubation of IL-I solutions with antibody to IL-I neutralized these actions. These pituitary effects of IL-I suggest that this monokine may be an important regulator of the metabolic adaptations to infectious stressors. Keywords Reprints. KT

Subject Categories:

  • Anatomy and Physiology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE