Accession Number:

ADA200034

Title:

Validation and Application of Pharmacokinetic Models for Interspecies Extrapolations in Toxicity Risk Assessments of Volatile Organics

Descriptive Note:

Annual rept. 1 Jul 1987-30 Jun 1988

Corporate Author:

GEORGIA UNIV ATHENS DEPT OF PHARMACOLOGY AND TOXICOLOGY

Report Date:

1988-08-30

Pagination or Media Count:

116.0

Abstract:

In pursuit of the goal of establishing a scientific basis for the interspecies extrapolation of pharmacokinetic data in health risk assessments, a series of studies have been conducted involving pharmacokinetic determinations in rats to be followed later in dogs to several aliphatic halocarbons. Direct measurements of the uptake and elimination of halocarbon in the blood and exhaled breath of rats have been completed during and following inhalation exposures to trichloroethylene TCE,trichloroethane TRI, and dichlorethylene DCE. Two manuscripts have been completed for publication in peer-reviewed journals on the work with inhaled TCE and TRI. pharmacokinetic determinations have also been made in studies of the ingestion of TCE, TRI, and DCE. Keywords Physiologically-based pharmacokinetic model, Saturable metabolism, Respiratory elimination, Halocarbon inhalation exposure, Halocarbon oral exposure, Interspecies extrapolations, Pharmacokinetics, 1,1,1-Trichloroethane, 1,1- Dichloroethylene.

Subject Categories:

  • Toxicology
  • Pharmacology
  • Theoretical Mathematics

Distribution Statement:

APPROVED FOR PUBLIC RELEASE